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Year : 2022  |  Volume : 1  |  Issue : 4  |  Page : 166-172

Neural rewiring from peripheral to central: a narrative review

1 School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine; Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation, Ministry of Education, Shanghai, China
2 Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, Milwaukee, WI, USA

Correspondence Address:
Ji-Geng Yan
Department of Plastic and Reconstructive Surgery, Medical College of Wisconsin, Milwaukee, WI, USA
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2773-2398.365026

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Peripheral nerve injury and reconstruction would lead to alteration of neural pathways. This is regarded as rewiring peripheral nerves, which could also be a trigger for the corresponding neural rewiring process in the brain. Brain plasticity subsequent to peripheral nerve reconstruction plays an important role in the functional recovery of limbs, which has attracted increasing concerns. The present study aimed to overview recent progress in neuroregeneration-related brain plasticity. Nerve transfer is a special technique of nerve reconstruction that usually leads to substantial peripheral neural rewiring and cortical reorganization. Nerve transfer-related shifting of motor representation was particularly discussed. We also emphasized rehabilitation strategies based on the current peripheral-central rewiring theory. Specific strategies based on neural plasticity were proposed for corresponding recovery stages.

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